RESUMO
Three novel series of 1H-benzotriazole derivatives containing oxadiazole or oxadiazoline moiety were synthesized, namely; 1-[3- substituted methyl 1, 3, 4-oxadiazole-2[3H]-thion-5-yl]methyl 1-H- benzotriazoles, 1-[2-substituted amino-1, 3, 4-oxadiazol-5-yl] methyl-1H-benzotriazoles and 1-[3-acetyl-5aryl-2, 3-dihydro-1, 3, 4- oxadiazol-2-yl] methyl-1H-benzotriazoles. The antimicrobial testing of the final compounds as well as the key intermediates was performed
Assuntos
Farmacologia , AntibioseRESUMO
Novel series of fused hetercycles, namely; 6-substituted-3-[2-phenylquinol-4-yl]-1, 2, 4-triazolo [3, 4-b] [1, 3, 4] thiadiazoles; 6-substituted-3-[2-phenylquinol -4-yl]-7H-1, 2, 4-triazolo [3, 4-b] [1, 3, 4] thiadiazines and 7-ethoxycarbonyl and 7-substituted carbamoyl-6-methyl-3-[2-phenylquinol-4-yl] -5H-1, 2, 4-triazolo [3, 4-b] [1, 3, 4] thiadiazines were synthesized and evaluated for antibacterial and antifungal activities